Studiene fant at i de fleste tilfeller var de høyere dosene mindre effektive enn one mg-dosen og hadde mer negative bivirkninger. Maksimal anbefalt dose er 4 mg per dag.Distribusjonsvolumet vil være ca. 5 liter hos et voksent menneske for et legemiddel som hovedsakelig befinner seg i plasma.Reserver samtidig forskrivning av disse legemidlene til
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